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Invitrogen
BAFF Polyclonal Antibody
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FIGURE: 1 / 5
BAFF Antibody (PA5-19941) in ICC/IF
Immunocytochemistry of HL60 cells using BAFF Polyclonal Antibody (Product # PA5-19941) at 1 µg/mL. Cells were fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4°C. A goat anti-rabbit IgG H&L (HRP) at 1:250 was used as secondary. Counter stained with Hematoxylin.
Product Details
PA5-19941
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A peptide corresponding to amino acids near the carboxy terminus of human BAFF.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Ion-exchange chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is HL60 cell lysate.
PA5-19941 can be used with blocking peptide PEP-0066.
Target Information
BAFF is a membrane bound cytokine expressed by B cell lineage cells. The soluble form of the cytokine binds to the receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is a potent B cell activator, and important for the proliferation and differentiation of B cells. BAFF is also expressed by T lymphocytes and has been shown to promote T cell activation and survival. Isoforms representing alternatively spliced, and glycosylated variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ApoL related ligand TALL-1; b cell-activating factor; B lymphocyte stimulator; B-cell activating factor; B-cell-activating factor; B-lymphocyte stimulator; BAFF; BLyS; CD257; delta BAFF; Delta4 BAFF; Dendritic cell-derived TNF-like molecule; epididymis secretory sperm binding protein; TALL-1; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; TNF ligand superfamily member; TNF- and APOL-related leukocyte expressed ligand 1; TNF-like cytokine; TNFSF13B; tumor necrosis factor (ligand) superfamily, member 13b; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor ligand 7A; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor superfamily member 13b; tumor necrosis factor-like protein ZTNF4
Gene Aliases: BAFF; BLYS; CD257; D8Ertd387e; DTL; RGD1561519; TALL-1; TALL1; THANK; TNFSF13B; TNFSF20; TNLG7A; UNQ401/PRO738; ZTNF4
UniProt ID: (Human) Q9Y275, (Mouse) Q9WU72
Entrez Gene ID: (Human) 10673, (Mouse) 24099, (Rat) 498666
B cell homeostasis
positive regulation of germinal center formation
immune response
positive regulation of B cell proliferation
T cell costimulation
B cell costimulation
positive regulation of T cell proliferation
immunoglobulin secretion
regulation of immune response
lymphocyte homeostasis
transitional one stage B cell differentiation
immune system process
germinal center formation
cell communication
signal transduction
signaling
B cell differentiation
tumor necrosis factor-mediated signaling pathway
T cell proliferation
B cell proliferation
skin development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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