PA5-27709 targets Bag1 in IF and WB applications and shows reactivity with Human samples.
The PA5-27709 immunogen is recombinant fragment corresponding to a region within amino acids 151 and 345 of Human Bag1.
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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) start site, and alternative, downstream, AUG translation initiation sites.
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Protein Aliases: 46-KD; BAG family molecular chaperone regulator 1; BAG-1; Bcl-2 associating athanogene-1 protein; Bcl-2-associated athanogene 1; Bcl-2-binding protein; BCL2-associated athanogene; glucocortoid receptor-associated protein RAP46; RAP46; receptor-associated protein; receptor-associated protein, 46-KD
Gene Aliases: BAG-1; BAG1; HAP; RAP46
UniProt ID: (Human) Q99933
Entrez Gene ID: (Human) 573