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Invitrogen
BAG4 Polyclonal Antibody
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FIGURE: 1 / 3
BAG4 Antibody (PA5-106815) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded BAG4 in rat lung tissue. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with BAG4 polyclonal antibody (Product # PA5-106815) using a dilution of 1:100 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-106815
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BAG4(Accession O95429), corresponding to amino acid residues N329-S379.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BAG4.
Target Information
The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAG family molecular chaperone regulator 4; BAG-4; Bcl-2-associated athanogene 4; BCL2 associated athanogene 4; Silencer of death domains; unnamed protein product
Gene Aliases: 2410112I15Rik; BAG-4; BAG4; SODD
UniProt ID: (Human) O95429, (Mouse) Q8CI61
Entrez Gene ID: (Human) 9530, (Mouse) 67384, (Rat) 361167
protein folding
positive regulation of fibroblast migration
positive regulation of actin filament polymerization
negative regulation of apoptotic process
positive regulation of cell adhesion
protein stabilization
positive regulation of stress fiber assembly
positive regulation of protein kinase B signaling
cellular response to tumor necrosis factor
cellular response to epidermal growth factor stimulus
protein localization to plasma membrane
negative regulation of mRNA modification
ruffle assembly
negative regulation of protein targeting to mitochondrion
apoptotic process
positive regulation of peptidyl-serine phosphorylation
regulation of apoptotic process
protein heterooligomerization
negative regulation of phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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