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Invitrogen
BAG6 Polyclonal Antibody
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FIGURE: 1 / 1
BAG6 Antibody (PA5-96033) in WB
Western blot analysis of BAG6 in extracts of various cell lines. Samples were incubated with BAG6 Polyclonal antibody (Product # PA5-96033) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96033
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human BAT3/BAT3/BAG6 (NP_0010920041)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
22 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGSPPGTRGP GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL SRMECRGGPQ PQHSQPPPQP; Positive Samples: 293T, HeLa, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus, cytosol
Target Information
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAG 6; BAG family molecular chaperone regulator 6; BAG-6; BAT 3; BCL2 associated athanogene 6; BCL2-associated athanogene 6; DAQB-195H10.3; HLA-B associated transcript 3; HLA-B-associated transcript 3; HLA-B-associated transcript 3 (BAT3); Large proline-rich protein BAG6; large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe; unnamed protein product
Gene Aliases: 2410045D21Rik; AA408914; BAG-6; BAG6; BAT3; D17H6S52E; D6S52E; G3; Scythe
UniProt ID: (Human) P46379, (Rat) Q6MG49, (Mouse) Q9Z1R2
Entrez Gene ID: (Human) 7917, (Rat) 94342, (Mouse) 224727
receptor binding
protein binding
Hsp70 protein binding
polyubiquitin binding
ubiquitin protein ligase binding
identical protein binding
ribosome binding
receptor agonist activity
misfolded protein binding
binding, bridging
proteasome binding
protein carrier chaperone
ubiquitin-specific protease binding
chaperone
kidney development
immune system process
immune response-activating cell surface receptor signaling pathway
chromatin organization
ubiquitin-dependent protein catabolic process
posttranslational protein targeting to membrane
apoptotic process
synaptonemal complex assembly
spermatogenesis
brain development
proteasomal protein catabolic process
internal peptidyl-lysine acetylation
natural killer cell activation
cell differentiation
lung development
regulation of protein stability
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
ERAD pathway
maintenance of unfolded protein
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
regulation of apoptotic process
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of proteolysis
regulation of embryonic development
protein stabilization
NK T cell activation
endoplasmic reticulum stress-induced pre-emptive quality control
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
transport
chromatin modification
regulation of cell proliferation
antigen processing and presentation of peptide antigen via MHC class I
embryo development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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