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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||KLH conjugated synthetic peptide between 492-518 amino acids from the C-terminal region of human BAIAP2|
|Purification||Size-exclusion - Dialysis, Ammonium sulfate precipitation|
|Contains||0.09% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
BAIAP2, a target of p53, has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
BAI-associated protein 2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; fas ligand-associated factor 3; insulin receptor substrate of 53 kDa; insulin receptor substrate p53; insulin receptor substrate p53/p58; insulin receptor substrate protein of 53 kDa; insulin receptor tyrosine kinase 53 kDa substrate; IRS-58; IRSp53/58
BAIAP2; BAP2; FLAF3; IRSP53; R75030