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Search Thermo Fisher Scientific
Invitrogen
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.
Immunogen sequence: DYLECLSMGA AADRRADSAR TTSTFKAPAS KPETAAPNDA NGTAKPPFLS GENPFATVKL RPTVTNDRSA P
Highest antigen sequence identity to the following orthologs: Mouse - 71%, Rat - 75%.
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; BAR/IMD domain-containing adapter protein 2-like 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
Gene Aliases: BAIAP2L1; IRTKS
UniProt ID: (Human) Q9UHR4
Entrez Gene ID: (Human) 55971
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