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Product Details
A304-830A
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
Assay-dependent | - |
Immunoprecipitation (IP) |
2-10 µg/mg lysate | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Between 425 and 475 |
Conjugate |
Unconjugated |
Form |
liquid |
Concentration |
1 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
phosphate/tris citrate, pH 7-8 |
Contains |
0.09% sodium azide |
Storage conditions |
4° C |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BAI1-associated protein 2-like 1; BAI1-associated protein 2-like protein 1; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate
Gene Aliases: BAIAP2L1; IRTKS
UniProt ID: (Human) Q9UHR4
Entrez Gene ID: (Human) 55971
Molecular Function:
scaffold/adaptor protein
plasma membrane organization
insulin receptor signaling pathway
response to bacterium
positive regulation of actin filament polymerization
regulation of insulin receptor signaling pathway
actin filament bundle assembly
actin crosslink formation
cell-cell adhesion
positive regulation of actin cytoskeleton reorganization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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