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Invitrogen
BAK Polyclonal Antibody
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Product Details
PA5-120028
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human Bak (NP_0011791)
Conjugate
Form
Liquid
Concentration
2.11 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: THP-1. The target is usually found in the following locations: Mitochondrion membrane, Single-pass membrane protein.
Immunogen sequence: EGVAAPADPE MVTLPLQPSS TMGQVGRQLA IIGDDINRRY DSEFQTMLQH LQPTAENAYE YFTKIATSLF ESGINWGRVV ALLGFGYRLA LHVYQHGLTG F
Target Information
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and functions to induce apoptosis. It interacts with and accelerates the opening of the mitochondrial voltage-dependent anion channel, which leads to a loss in membrane potential and the release of cytochrome c. This protein also interacts with the tumor suppressor P53 after exposure to cell stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apoptosis regulator BAK; Bcl-2 homologous antagonist/killer; Bcl-2-like protein 7; Bcl2 homologous antagonist/killer; BCL2-antagonist/killer 1; Bcl2-L-7; BCL2-like 7 protein; BCL2-like 7protein; MGC117255; MGC3887; pro-apoptotic protein BAK
Gene Aliases: BAK; BAK-LIKE; BAK1; BCL2L7; CDN1; N-Bak; N-BAK1
UniProt ID: (Human) Q16611, (Mouse) O08734
Entrez Gene ID: (Human) 578, (Mouse) 12018, (Rat) 116502
leukocyte homeostasis
B cell homeostasis
B cell apoptotic process
release of cytochrome c from mitochondria
blood vessel remodeling
myeloid cell homeostasis
B cell negative selection
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
mitochondrial fusion
cell proliferation
negative regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
response to fungus
response to mycotoxin
establishment or maintenance of transmembrane electrochemical gradient
response to gamma radiation
positive regulation of calcium ion transport into cytosol
negative regulation of gene expression
cytolysis
negative regulation of endoplasmic reticulum calcium ion concentration
negative regulation of peptidyl-serine phosphorylation
cellular response to UV
limb morphogenesis
regulation of apoptotic process
positive regulation of apoptotic process
regulation of protein homodimerization activity
regulation of protein heterodimerization activity
fibroblast apoptotic process
positive regulation of proteolysis
regulation of mitochondrial membrane permeability
post-embryonic camera-type eye morphogenesis
homeostasis of number of cells
regulation of cell cycle
regulation of mitochondrial membrane potential
vagina development
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
thymocyte apoptotic process
positive regulation of release of cytochrome c from mitochondria
apoptotic signaling pathway
extrinsic apoptotic signaling pathway in absence of ligand
activation of cysteine-type endopeptidase activity
positive regulation of endoplasmic reticulum unfolded protein response
apoptotic process involved in patterning of blood vessels
brain development
aging
response to UV-C
response to organic cyclic compound
endocrine pancreas development
organ regeneration
response to drug
response to hydrogen peroxide
response to ethanol
cellular response to mechanical stimulus
activation of signaling protein activity involved in unfolded protein response
endoplasmic reticulum calcium ion homeostasis
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
positive regulation of IRE1-mediated unfolded protein response
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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