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BAMBI Polyclonal Antibody
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FIGURE: 1 / 2
BAMBI Antibody (BS-12418R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded Human Kidney Tissue; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15 minutes; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20 minutes; Antibody incubation with BAMBI Polyclonal Antibody, Unconjugated (bs-12418R) at 1:200 overnight at 4°C, followed by a conjugated secondary anti... View More
Product Details
BS-12418R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human BAMBI, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines; similar to EST encoded by GenBank Accession Number T73919; putative transmembrane protein; Kinase-deficient TGFbeta superfamily receptor subunit; Non-metastatic gene A protein; Putative transmembrane protein NMA; unnamed protein product
Gene Aliases: 2610003H06Rik; BAMBI; NMA
UniProt ID: (Human) Q13145, (Rat) Q91XN4, (Mouse) Q9D0L6
Entrez Gene ID: (Human) 25805, (Pig) 449001, (Rat) 83837, (Mouse) 68010
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
positive regulation of protein binding
positive regulation of catenin import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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