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Invitrogen
BAMBI Polyclonal Antibody
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FIGURE: 1 / 1
BAMBI Antibody (PA5-47962) in IHC (P)
Immunohistochemical analysis of BAMBI in immersion fixed paraffin-embedded sections of human kidney. Samples were incubated in BAMBI polyclonal antibody (Product # PA5-47962) using a dilution of 3 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue). Specific staining was localized to cytoplasm in tubular epithe... View More
Product Details
PA5-47962
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant human BAMBI/NMA Glu27-Ala152
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP and activin membrane-bound inhibitor homolog; expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines; similar to EST encoded by GenBank Accession Number T73919; putative transmembrane protein; Non-metastatic gene A protein; Putative transmembrane protein NMA; unnamed protein product
Gene Aliases: BAMBI; NMA
UniProt ID: (Human) Q13145
Entrez Gene ID: (Human) 25805
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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