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Invitrogen
BAMBI Polyclonal Antibody
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FIGURE: 1 / 3
BAMBI Antibody (PA5-80372) in WB
Western blot was performed using Anti-BAMBI Polyclonal Antibody (Product # PA5-80372) and a 40 kDa band corresponding to BMP and activin membrane-bound inhibitor homolog was observed across tissues tested. Tissue extracts (30 µg lysate) of Mouse Liver (Lane 1), Mouse Brain (Lane 2), Mouse Skeletal Muscle (Lane 3), Mouse Mammary gland (Lane 4) and Rat Mammary gland (Lane 5) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0321BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # IB... View More
Product Details
PA5-80372
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human BAMBI protein (Met1-Ala152)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human BAMBI/NMA.
Target Information
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; Kinase-deficient TGFbeta superfamily receptor subunit; Non-metastatic gene A protein; Putative transmembrane protein NMA
Gene Aliases: 2610003H06Rik; BAMBI; NMA
UniProt ID: (Human) Q13145, (Rat) Q91XN4, (Mouse) Q9D0L6
Entrez Gene ID: (Human) 25805, (Rat) 83837, (Mouse) 68010
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
positive regulation of protein binding
positive regulation of catenin import into nucleus
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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