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Invitrogen
BAMBI Polyclonal Antibody
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FIGURE: 1 / 2
BAMBI Antibody (PA5-93037) in WB
Western blot was performed using Anti-BAMBI Polyclonal Antibody (Product # PA5-93037) and a ~40 kDa band corresponding to BMP and activin membrane-bound inhibitor homolog was detected in Mouse Mammary Gland tissue and not in Mouse Brain or Skeletal Muscle which are reported low expressing for BAMBI. Uncharacterized bands (*) at ~45 kDa, ~80 kDa and ~110 kDa are also detected in the low expressing models. Tissue extracts (30 µg lysate) of Mouse Mammary Gland (Lane 1), Mouse Brain (Lane 2), Mouse Skeletal Muscle (Lane 3) were electrophoresed... View More
Product Details
PA5-93037
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 21-152 of human BAMBI (NP_0364741)
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Amount
20 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VLLTKGEIRC YCDAAHCVAT GYMCKSELSA CFSRLLDPQN SNSPLTHGCL DSLASTTDIC QAKQARNHSG TTIPTLECCH EDMCNYRGLH DVLSPPRGEA SGQGNRYQHD GSRNLITKVQ ELTSSKELWF RA; Positive Samples: A-549, Rat heart; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
BAMBI (BMP and activin membrane-bound inhibitor homolog, NMA) is a membrane spanning glycoprotein that acts as a negative regulator of TGF-beta signaling during development. BAMBI transcription regulation is under the influence of beta-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP and activin membrane-bound inhibitor homolog; BMP and activin membrane-bound inhibitor, homolog; expression in poorly metastatic human melanoma cell lines; no expression in highly metastatic human melanoma cell lines; similar to EST encoded by GenBank Accession Number T73919; putative transmembrane protein; Kinase-deficient TGFbeta superfamily receptor subunit; Non-metastatic gene A protein; Putative transmembrane protein NMA; unnamed protein product
Gene Aliases: BAMBI; NMA
UniProt ID: (Human) Q13145, (Rat) Q91XN4
Entrez Gene ID: (Human) 25805, (Rat) 83837
transforming growth factor beta receptor signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of epithelial to mesenchymal transition
cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of canonical Wnt signaling pathway
positive regulation of protein binding
positive regulation of catenin import into nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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