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Invitrogen
BANF1 Polyclonal Antibody
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Product Details
PA5-20329
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 19 amino acid peptide from near the amino terminus of human BANF1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Despite its predicted molecular weight, BANF1 often migrates at a higher molecular weight in SDS-PAGE. A suggested positive control is mouse kidney tissue lysate.
PA5-20329 can be used with blocking peptide PEP-0449.
Target Information
Barrier-to-autointegration factor 1 (BANF1) is a conserved chromatin protein that non-specifically binds double-stranded DNA. BANF1 also interacts with a family of nuclear proteins that include LAP2, emerin, and MAN1. It is also a host cell component of retroviral pre-integration complexes (PICs), including that of HIV. BANF1 will bind to p55 Gag (the structural precursor of HIV-1 virions) as well as its cleaved product matrix. In addition to being a host cell component of the PIC, it is thought that BANF1 is also present at low levels in incoming virions, and thus might contribute to the assembly or activity of HIV-1 PICs through direct binding to matrix as well as DNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAF nuclear assembly factor 1; BANF1; barrier to autointegration factor 1; Barrier-to-autointegration factor; Breakpoint cluster region protein 1; Breakpoint cluster region protein, uterine leiomyoma, 1; Breakpoint cluster region protein, uterine leiomyoma, 1; barrier to autointegration factor; homolog to Mus musculus BAF; Lap2 binding protein 1; LAP2-binding protein 1; similar to Mus musculus barrier-to-autointegration factor; unnamed protein product
Gene Aliases: BAF; BANF1; BCRG1; BCRP1; D14S1460; L2bp1; L2bp1/Baf; NGPS
UniProt ID: (Human) O75531, (Mouse) O54962, (Rat) Q9R1T1
Entrez Gene ID: (Human) 8815, (Mouse) 23825, (Rat) 114087
DNA integration
establishment of integrated proviral latency
DNA repair
chromatin organization
response to oxidative stress
mitotic nuclear envelope reassembly
response to virus
negative regulation of protein ADP-ribosylation
negative regulation of type I interferon production
positive regulation of type I interferon production
negative regulation of viral genome replication
negative regulation of innate immune response
chromosome organization
cGAS/STING signaling pathway
negative regulation of cGAS/STING signaling pathway
regulation of viral process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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