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Invitrogen
BAP31 Polyclonal Antibody
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FIGURE: 1 / 3
BAP31 Antibody (PA5-20199) in IHC (P)
Immunohistochemical analysis of paraffin-embedded rat lung tissue using BAP31 Polyclonal Antibody (Product # PA5-20199) at 10 µg/mL. Tissue was fixed with formaldehyde and blocked with 0.1 serum for 1 h at RT; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody overnight at 4˚C. A goat anti-rabbit IgG H&L (HRP) at 1/250 was used as secondary. Cou... View More
Product Details
PA5-20199
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 17 amino acid peptide from near the center of human BAP31.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat lung tissue lysate.
PA5-20199 can be used with blocking peptide PEP-0327.
Target Information
BAP31 (B-Cell Receptor Associated Protein, 31-kDa) is a multiple membrane spanning protein of the endoplasmic reticulum. It has been shown to form both homo- and hetero-oligomers with the closely related BAP29, and is a potential apoptotic regulator as a predicted BCL-2/BCL-XL-associated protein. In the C-terminal domain of BAP31, there are two identical recognition sites for initiator Caspases 1 and 8 of the programmed death cascade. It is hypothesized that BAP31 plays a role in the transport of selected proteins to the Golgi apparatus. BAP31 has also been shown to control expression of CFTR (cystic fibrosis transmembrane conductance regulator). It is believed that interference with the expression or function of BAP31 in epithelial cells may be a way to circumvent the chloride channel defect in cystic fibrosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 6C6 antigen; 6C6-AG tumor-associated antigen; accessory protein BAP31; B-cell receptor-associated protein 31; BCR-associated protein 31; BCR-associated protein Bap31; CDM protein; OTTHUMP00000025978; p28; p28 Bap31; Protein CDM; unnamed protein product
Gene Aliases: 6C6-AG; BAP31; BCAP31; CDM; DDCH; DELXQ28; DXS1357E; MICRODELXq28
UniProt ID: (Human) P51572, (Mouse) Q61335
Entrez Gene ID: (Human) 10134, (Rat) 293852, (Mouse) 27061
protein targeting to mitochondrion
intracellular protein transport
ER to Golgi vesicle-mediated transport
apoptotic process
spermatogenesis
protein transport
vesicle-mediated transport
response to endoplasmic reticulum stress
protein localization to endoplasmic reticulum exit site
positive regulation of retrograde protein transport, ER to cytosol
positive regulation of ERAD pathway
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of intrinsic apoptotic signaling pathway
immune response
positive regulation of cytosolic calcium ion concentration
biological_process
negative regulation of endoplasmic reticulum calcium ion concentration
calcium-mediated signaling using intracellular calcium source
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of mitochondrial calcium ion concentration
transport
positive regulation of ER-associated ubiquitin-dependent protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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