Sequence homology: Cow: 86%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Yeast: 83%
BATF3, also known as SNFT, belongs to the basic leucine zipper transcriptional family and functions as a transcriptional repressor when heterodimerizing with Jun and can repress the transcription of IL-2 and MMP-1. BATF3 is required for the development of CD8alpha+ classical dendritic cells (DCs) and the related CD103+ DCs that cross-present antigens to CD8 T cells.
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Protein Aliases: 21 kDa small nuclear factor isolated from T-cells; 21-kD small nuclear factor isolated from T cells; B-ATF-3; basic leucine zipper transcription factor, ATF-like 3; Basic leucine zipper transcriptional factor ATF-like 3; Jun dimerization protein 1; Jun dimerization protein p21SNFT
Gene Aliases: BATF3; JDP1; JUNDM1; SNFT
UniProt ID: (Human) Q9NR55
Entrez Gene ID: (Human) 55509
Molecular Function: basic leucine zipper transcription factor