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Invitrogen
BAZ2A Polyclonal Antibody
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FIGURE: 1 / 2
BAZ2A Antibody (49-1037) in WB
Western blot analysis using the anti-TIP5 crude serum. Nuclear extracts (150 µg) from NIH3T3 or HeLa cells were analyzed by western blot using the anti-TIP5 crude serum (Product # 49-1037), diluted 1:1,000 in PBS containing 5% milk powder and 0.1% Tween-20. The molecular weight marker is shown on the left, the location of the protein of interest is indicated on the right.
Product Details
49-1037
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein TIP5
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
<0.1% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
TIP 5 is the large subunit of the nucleolar remodeling complex NoRC. NoRC causes the repression of ribosomal gene transcription. It was demonstrated that histone deacetylation is involved in this repression and that TIP5 is associated with the histone deacetylase HDAC1 and mediates the deacetylation of histones in the vicinity of the rDNA promoter. The interaction of TIP5 and HDAC1, which is necessary for transcriptional repression, is established by the C-terminal PHD finger and bromodomain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bromodomain adjacent to zinc finger domain protein 2A; hWALp3; Transcription termination factor I-interacting protein 5; TTF-I interacting peptide 5; TTF-I-interacting protein 5; unnamed protein product
Gene Aliases: AA415431; BAZ2A; C030005G16Rik; C78388; KIAA0314; mKIAA0314; TIP5; WALp3
UniProt ID: (Human) Q9UIF9
Entrez Gene ID: (Human) 11176, (Mouse) 116848
RNA polymerase I CORE element sequence-specific DNA binding
DNA binding
RNA binding
protein binding
zinc ion binding
ligand-dependent nuclear receptor binding
histone binding
metal ion binding
histone H4K16ac reader activity
lysine-acetylated histone binding
chromatin/chromatin-binding, or -regulatory protein
chromatin silencing at rDNA
RNA polymerase I preinitiation complex assembly
chromatin organization
chromatin remodeling
methylation-dependent chromatin silencing
transcription, DNA-templated
regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase I promoter
heterochromatin assembly
DNA methylation
chromatin modification
histone deacetylation
histone H4-K20 methylation
histone H3-K9 methylation
heterochromatin assembly involved in chromatin silencing
histone H4 deacetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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