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Proteintech
BBS10 Polyclonal Antibody
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Product Details
12421-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BBS10 Fusion Protein Ag3073 (573-723 aa encoded by BC013795)
Conjugate
Form
Liquid
Concentration
0.29 mg/mL
Amount
43.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLPVSCKLP NMGTSQSYLS SSMPAGCVLP VGGNFEILLH YYLLNYAKKC HQSEETMVSM IIANALLGIP KVLYKSKTGK YSFPHTYIRA VHALQTNQPL VSSQTGLESV MGKYQLLTSV LQCLTKILTI DMVITVKRHP QKVHNQDSED EL (573-723 aa encoded by BC013795)
Target Information
BBS10 is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by progressive retinal degeneration, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene is likely not a ciliary protein but rather has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 10 protein; BBSome complex assembly protein BBS10; unnamed protein product
Gene Aliases: BBS10; C12orf58
UniProt ID: (Human) Q8TAM1
Entrez Gene ID: (Human) 79738
visual perception
protein localization
response to light stimulus
neuronal action potential
response to endoplasmic reticulum stress
retinal cone cell differentiation
regulation of protein complex assembly
negative regulation of neuron apoptotic process
photoreceptor cell maintenance
photoreceptor cell differentiation
chaperone-mediated protein complex assembly
retina development in camera-type eye
retinal rod cell differentiation
cone retinal bipolar cell differentiation
non-motile cilium assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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