Proteintech

BBS2 Polyclonal Antibody

View all (9) BBS2 antibodies

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BBS2 Antibody in Immunocytochemistry (ICC/IF) — IF result (cilia stain) of anti-BBS2 (11188-2-AP, 1:50) with serum-starved hTERT-RPE1 cells by Dr. Moshe Kim.

BBS2 Antibody in Western Blot (WB) — Mouse testis tissue were subjected to SDS PAGE followed by western blot with 11188-2-AP (BBS2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

BBS2 Antibody in Immunoprecipitation (IP) — IP result of anti-BBS2 (IP:11188-2-AP, 4ug; Detection:11188-2-AP 1:300) with mouse testis tissue lysate 4000ug.

Product Details

11188-2-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:1,000	View 3 publications 3 publications
Immunohistochemistry (IHC)	Assay-dependent	View 2 publications 2 publications
Immunocytochemistry (ICC/IF)	1:20-1:200	View 4 publications 4 publications
Immunoprecipitation (IP)	0.5-4.0 µg	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human, Mouse, Rat
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	BBS2 Fusion Protein Ag1662 (1-325 aa encoded by BC014140) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.33 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MLLPVFTLK LRHKISPRMV AIGRYDGTHP CLAAATQTGK VFIHNPHTRN QHVSASRVFQ SPLESDVSLL NINQAVSCLT AGVLNPELGY DALLVGTQTN LLAYDVYNNS DLFYREVADG ANVVVLGTLG DISSPLAIIG GNCALQGFNH EGSDLFWTVT GDNVNSLALC DFDGDGKKEL LVGSEDFDIR VFKEDEIVAE MTETEIVTSL CPMYGSRFGY ALSNGTVGVY DKTSRYWRIK SKNHAMSIHA FDLNSDGVNE LITGWSNGKV DARSDRTGEV IFKDNFSSAI AGVVEGDYRM DGHIQLICCS VDGEIRGYLP GTAEMR (1-325 aa encoded by B C014140)

Target Information

This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Inhibition of Hedgehog signaling suppresses proliferation and microcyst formation of human Autosomal Dominant Polycystic Kidney Disease cells.

Scientific reports

Silva LM,Jacobs DT,Allard BA,Fields TA,Sharma M,Wallace DP,Tran PV

Wed Mar 21 00:00:00 EDT 2018

Refining genotype-phenotype correlation in Alström syndrome through study of primary human fibroblasts.

Molecular genetics & genomic medicine

Chen JH,Geberhiwot T,Barrett TG,Paisey R,Semple RK

Sat Jul 01 00:00:00 EDT 2017

A novel form of ciliopathy underlies hyperphagia and obesity in Ankrd26 knockout mice.

Brain structure & function

Acs P,Bauer PO,Mayer B,Bera T,Macallister R,Mezey E,Pastan I

Fri Jan 15 00:00:00 EST 2016

Essential role of the chaperonin CCT in rod outer segment biogenesis.

Investigative ophthalmology & visual science

Sinha S,Belcastro M,Datta P,Seo S,Sokolov M

Thu May 22 00:00:00 EDT 2014

A truncating mutation of Alms1 reduces the number of hypothalamic neuronal cilia in obese mice.

Developmental neurobiology

Heydet D,Chen LX,Larter CZ,Inglis C,Silverman MA,Farrell GC,Leroux MR

Tue Jan 01 00:00:00 EST 2013

Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.

Cell stem cell

Kusek G,Campbell M,Doyle F,Tenenbaum SA,Kiebler M,Temple S

Fri Oct 05 00:00:00 EDT 2012

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

Cell

Jin H,White SR,Shida T,Schulz S,Aguiar M,Gygi SP,Bazan JF,Nachury MV

Fri Jun 25 00:00:00 EDT 2010

Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions.

The Journal of comparative neurology

May-Simera HL,Ross A,Rix S,Forge A,Beales PL,Jagger DJ

Sun May 10 00:00:00 EDT 2009

Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions.

The Journal of comparative neurology

May-Simera HL,Ross A,Rix S,Forge A,Beales PL,Jagger DJ

Sun May 10 00:00:00 EDT 2009

Patterns of expression of Bardet-Biedl syndrome proteins in the mammalian cochlea suggest noncentrosomal functions.

The Journal of comparative neurology

May-Simera HL,Ross A,Rix S,Forge A,Beales PL,Jagger DJ

Sun May 10 00:00:00 EDT 2009

Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse.

Human molecular genetics

Jiang ST,Chiou YY,Wang E,Chien YL,Ho HH,Tsai FJ,Lin CY,Tsai SP,Li H

Fri May 01 00:00:00 EDT 2009

Bioinformatics

Protein Aliases: Bardet-Biedl syndrome 2 homolog; Bardet-Biedl syndrome 2 protein; Bardet-Biedl syndrome 2 protein homolog; MGC20703

Gene Aliases: 2410125H22Rik; AI447581; BBS; BBS2; RP74

UniProt ID: (Human) Q9BXC9, (Rat) Q99MH9, (Mouse) Q9CWF6

Entrez Gene ID: (Human) 583, (Rat) 113948, (Mouse) 67378

sperm axoneme assembly visual perception protein localization negative regulation of gene expression artery smooth muscle contraction striatum development hippocampus development cerebral cortex development adult behavior melanosome transport protein localization to organelle nonmotile primary cilium assembly negative regulation of appetite by leptin-mediated signaling pathway negative regulation of multicellular organism growth positive regulation of multicellular organism growth vasodilation cilium assembly Golgi to plasma membrane protein transport fat cell differentiation photoreceptor cell maintenance brain morphogenesis cartilage development cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility protein localization to ciliary membrane biological_process leptin-mediated signaling pathway response to leptin transport protein transport cell projection organization

Process(es)

RNA polymerase II repressing transcription factor binding protein binding molecular_function