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Proteintech
BBS2 Polyclonal Antibody
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Product Details
11188-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BBS2 Fusion Protein Ag1662 (1-325 aa encoded by BC014140)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLLPVFTLK LRHKISPRMV AIGRYDGTHP CLAAATQTGK VFIHNPHTRN QHVSASRVFQ SPLESDVSLL NINQAVSCLT AGVLNPELGY DALLVGTQTN LLAYDVYNNS DLFYREVADG ANVVVLGTLG DISSPLAIIG GNCALQGFNH EGSDLFWTVT GDNVNSLALC DFDGDGKKEL LVGSEDFDIR VFKEDEIVAE MTETEIVTSL CPMYGSRFGY ALSNGTVGVY DKTSRYWRIK SKNHAMSIHA FDLNSDGVNE LITGWSNGKV DARSDRTGEV IFKDNFSSAI AGVVEGDYRM DGHIQLICCS VDGEIRGYLP GTAEMR (1-325 aa encoded by B C014140)
Target Information
This gene is a member of the Bardet-Biedl syndrome (BBS) gene family. Bardet-Biedl syndrome is an autosomal recessive disorder characterized by severe pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation. The proteins encoded by BBS gene family members are structurally diverse and the similar phenotypes exhibited by mutations in BBS gene family members is likely due to their shared roles in cilia formation and function. Many BBS proteins localize to the basal bodies, ciliary axonemes, and pericentriolar regions of cells. BBS proteins may also be involved in intracellular trafficking via microtubule-related transport. The protein encoded by this gene forms a multiprotein BBSome complex with six other BBS proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Bardet-Biedl syndrome 2 homolog; Bardet-Biedl syndrome 2 protein; Bardet-Biedl syndrome 2 protein homolog; BBSome complex member BBS2; MGC20703
Gene Aliases: 2410125H22Rik; AI447581; BBS; BBS2; RP74
UniProt ID: (Human) Q9BXC9, (Rat) Q99MH9, (Mouse) Q9CWF6
Entrez Gene ID: (Human) 583, (Rat) 113948, (Mouse) 67378
sperm axoneme assembly
visual perception
protein localization
negative regulation of gene expression
artery smooth muscle contraction
striatum development
hippocampus development
cerebral cortex development
adult behavior
melanosome transport
protein localization to organelle
nonmotile primary cilium assembly
negative regulation of appetite by leptin-mediated signaling pathway
negative regulation of multicellular organism growth
positive regulation of multicellular organism growth
vasodilation
cilium assembly
Golgi to plasma membrane protein transport
fat cell differentiation
photoreceptor cell maintenance
brain morphogenesis
cartilage development
cilium morphogenesis
regulation of cilium beat frequency involved in ciliary motility
protein localization to ciliary membrane
biological_process
leptin-mediated signaling pathway
response to leptin
transport
protein transport
cell projection organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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