Proteintech

BBS4 Polyclonal Antibody

BBS4 Antibody in Immunocytochemistry (ICC/IF)

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BBS4 Antibody (12766-1-AP) in ICC/IF

IF result (cytoplasm and the length of cilia cilia stain) of anti-BBS4 (12766-1-AP; 1:50) with serum-starved hTERT-RPE1 cell (MeOH fixed) by Dr. Moshe Kim.

BBS4 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

12766-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:20-1:200

View 10 publications 10 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

BBS4 Fusion Protein Ag3430 (1-351 aa encoded by BC027624)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.14 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MAEERVATR TQFPVSTESQ KPRQKKAPEF PILEKQNWLI HLHYIRKDYE ACKAVIKEQL QETQGLCEYA IYVQALIFRL EGNIQESLEL FQTCAVLSPQ SADNLKQVAR SLFLLGKHKA AIEVYNEAAK LNQKDWEISH NLGVCYIYLK QFNKAQDQLH NALNLNRHDL TYIMLGKIHL LEGDLDKAIE VYKKAVEFSP ENTELLTTLG LLYLQLGIYQ KAFEHLGNAL TYDPTNYKAI LAAGSMMQTH GDFDVALTKY RVVACAVPES PPLWNNIGMC FFGKKKYVAA ISCLKRANYL APFDWKILYN LGLVHLTMQQ YASAFHFLSA AINFQPKMGE LYMLLAVALT NL (1-351 aa encoded by BC027624)

Target Information

BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.

Nature communications

Cao M,Zou X,Li C,Lin Z,Wang N,Zou Z,Ye Y,Seemann J,Levine B,Tang Z,Zhong Q

Mon Mar 27 00:00:00 UTC 2023

An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.

Nature communications

Cao M,Zou X,Li C,Lin Z,Wang N,Zou Z,Ye Y,Seemann J,Levine B,Tang Z,Zhong Q

Mon Mar 27 00:00:00 UTC 2023

The mechanism of acentrosomal spindle assembly in human oocytes.

Science (New York, N.Y.)

Wu T,Dong J,Fu J,Kuang Y,Chen B,Gu H,Luo Y,Gu R,Zhang M,Li W,Dong X,Sun X,Sang Q,Wang L

Fri Nov 18 00:00:00 UTC 2022

GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.

eLife

Jang DG,Kwon KY,Kweon YC,Kim BG,Myung K,Lee HS,Young Park C,Kwon T,Park TJ

Thu Aug 25 00:00:00 UTC 2022

Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.

EMBO reports

Arslanhan MD,Rauniyar N,Yates JR,Firat-Karalar EN

Wed Aug 04 00:00:00 UTC 2021

FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue.

Cell reports

Zhang Y,Hao J,Tarrago MG,Warner GM,Giorgadze N,Wei Q,Huang Y,He K,Chen C,Peclat TR,White TA,Ling K,Tchkonia T,Kirkland JL,Chini EN,Hu J

Tue Aug 03 00:00:00 UTC 2021

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.

eLife

Xiong Y,Scerbo MJ,Seelig A,Volta F,O'Brien N,Dicker A,Padula D,Lickert H,Gerdes JM,Berggren PO

Tue Nov 17 00:00:00 UTC 2020

Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.

EMBO reports

Odabasi E,Gul S,Kavakli IH,Firat-Karalar EN

Sat Jun 01 00:00:00 UTC 2019

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

PLoS biology

Haq N,Schmidt-Hieber C,Sialana FJ,Ciani L,Heller JP,Stewart M,Bentley L,Wells S,Rodenburg RJ,Nolan PM,Forsythe E,Wu MC,Lubec G,Salinas P,Häusser M,Beales PL,Christou-Savina S

Sun Sep 01 00:00:00 UTC 2019

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

PLoS biology

Haq N,Schmidt-Hieber C,Sialana FJ,Ciani L,Heller JP,Stewart M,Bentley L,Wells S,Rodenburg RJ,Nolan PM,Forsythe E,Wu MC,Lubec G,Salinas P,Häusser M,Beales PL,Christou-Savina S

Sun Sep 01 00:00:00 UTC 2019

Centrosomal and ciliary targeting of CCDC66 requires cooperative action of centriolar satellites, microtubules and molecular motors.

Scientific reports

Conkar D,Bayraktar H,Firat-Karalar EN

Thu Oct 03 00:00:00 UTC 2019

The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.

Autophagy

Struchtrup A,Wiegering A,Stork B,Rüther U,Gerhardt C

Thu Mar 07 00:00:00 UTC 2019

The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.

Autophagy

Struchtrup A,Wiegering A,Stork B,Rüther U,Gerhardt C

Thu Mar 07 00:00:00 UTC 2019

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

Nature communications

Krastev DB,Pettitt SJ,Campbell J,Song F,Tanos BE,Stoynov SS,Ashworth A,Lord CJ

Tue May 22 00:00:00 UTC 2018

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

Nature communications

Krastev DB,Pettitt SJ,Campbell J,Song F,Tanos BE,Stoynov SS,Ashworth A,Lord CJ

Tue May 22 00:00:00 UTC 2018

The CEP19-RABL2 GTPase Complex Binds IFT-B to Initiate Intraflagellar Transport at the Ciliary Base.

Developmental cell

Kanie T,Abbott KL,Mooney NA,Plowey ED,Demeter J,Jackson PK

Mon Jul 10 00:00:00 UTC 2017

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

The Journal of biological chemistry

Zhang B,Wang G,Xu X,Yang S,Zhuang T,Wang G,Ren H,Cheng SY,Jiang Q,Zhang C

Fri Jan 27 00:00:00 UTC 2017

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

The Journal of biological chemistry

Zhang B,Wang G,Xu X,Yang S,Zhuang T,Wang G,Ren H,Cheng SY,Jiang Q,Zhang C

Fri Jan 27 00:00:00 UTC 2017

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

The Journal of biological chemistry

Zhang B,Wang G,Xu X,Yang S,Zhuang T,Wang G,Ren H,Cheng SY,Jiang Q,Zhang C

Fri Jan 27 00:00:00 UTC 2017

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

The Journal of biological chemistry

Zhang B,Wang G,Xu X,Yang S,Zhuang T,Wang G,Ren H,Cheng SY,Jiang Q,Zhang C

Fri Jan 27 00:00:00 UTC 2017

BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.

Scientific reports

Prieto-Echagüe V,Lodh S,Colman L,Bobba N,Santos L,Katsanis N,Escande C,Zaghloul NA,Badano JL

Tue Aug 29 00:00:00 UTC 2017

BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.

Scientific reports

Prieto-Echagüe V,Lodh S,Colman L,Bobba N,Santos L,Katsanis N,Escande C,Zaghloul NA,Badano JL

Tue Aug 29 00:00:00 UTC 2017

BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.

Scientific reports

Prieto-Echagüe V,Lodh S,Colman L,Bobba N,Santos L,Katsanis N,Escande C,Zaghloul NA,Badano JL

Tue Aug 29 00:00:00 UTC 2017

BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1.

Scientific reports

Prieto-Echagüe V,Lodh S,Colman L,Bobba N,Santos L,Katsanis N,Escande C,Zaghloul NA,Badano JL

Tue Aug 29 00:00:00 UTC 2017

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.

Scientific reports

Xu Q,Zhang Y,Wei Q,Huang Y,Li Y,Ling K,Hu J

Tue Jul 07 00:00:00 UTC 2015

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors.

Scientific reports

Xu Q,Zhang Y,Wei Q,Huang Y,Li Y,Ling K,Hu J

Tue Jul 07 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: Bardet-Biedl syndrome 4 homolog; Bardet-Biedl syndrome 4 protein; Bardet-Biedl syndrome 4 protein homolog; BBSome complex member BBS4

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Gene Aliases: AW537059; AW742241; BBS4; D9Ertd464e

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UniProt ID: (Human) Q96RK4, (Mouse) Q8C1Z7

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Entrez Gene ID: (Human) 585, (Mouse) 102774, (Rat) 300754

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Function(s)

RNA polymerase II repressing transcription factor binding microtubule motor activity protein binding dynactin binding alpha-tubulin binding beta-tubulin binding molecular_function

Process(es)

microtubule cytoskeleton organization mitotic cytokinesis neural tube closure retina homeostasis negative regulation of systemic arterial blood pressure transport spermatid development sensory perception of smell protein localization metabolic process negative regulation of gene expression protein transport dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior negative regulation of actin filament polymerization regulation of cytokinesis leptin-mediated signaling pathway protein localization to organelle negative regulation of GTPase activity microtubule anchoring at centrosome nonmotile primary cilium assembly social behavior photoreceptor cell outer segment organization negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth cilium assembly response to leptin photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development brain morphogenesis centrosome organization maintenance of protein location in nucleus regulation of stress fiber assembly cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility face development fat pad development protein localization to cilium protein localization to centrosome regulation of nonmotile primary cilium assembly protein localization to photoreceptor outer segment neuron migration heart looping visual perception melanosome transport fat cell differentiation intracellular transport sensory processing biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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BBS4 Polyclonal Antibody

BBS4 Antibody (12766-1-AP) in ICC/IF

Product Details

12766-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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