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BBS4 Polyclonal Antibody

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BBS4 Polyclonal Antibody

Product Details

BS-11508R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human BBS4, amino acids 431-519.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

BBS4 contains tetratricopeptide repeats (TPR), similar to O-linked N-acetyglucosamine transferase. Mutations in the gene encoding this protein have been observed in patients with Bardet-Biedl syndrome type 4. BBS4 may play a role in pigmentary retinopathy, obesity, polydactyly, renal malformation and mental retardation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bardet-Biedl syndrome 4 homolog; Bardet-Biedl syndrome 4 protein; Bardet-Biedl syndrome 4 protein homolog; BBS4; BBSome complex member BBS4; unnamed protein product

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Gene Aliases: AW537059; AW742241; BBS4; D9Ertd464e

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UniProt ID: (Human) Q96RK4, (Mouse) Q8C1Z7

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Entrez Gene ID: (Human) 585, (Mouse) 102774, (Rat) 300754

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Function(s)
protein binding protein binding, bridging dynactin binding alpha-tubulin binding beta-tubulin binding RNA polymerase II sequence-specific DNA binding transcription factor binding RNA polymerase II repressing transcription factor binding microtubule motor activity molecular_function
Process(es)
microtubule cytoskeleton organization mitotic cytokinesis neuron migration leukocyte homeostasis B cell homeostasis neural tube closure retina homeostasis heart looping lymphocyte homeostasis myeloid cell homeostasis negative regulation of systemic arterial blood pressure centrosome cycle spermatid development sensory perception visual perception sensory perception of smell protein localization gene expression negative regulation of gene expression protein transport Wnt signaling pathway dendrite development regulation of lipid metabolic process ventricular system development striatum development hippocampus development cerebral cortex development cell projection organization adult behavior negative regulation of actin filament polymerization melanosome transport regulation of cytokinesis leptin-mediated signaling pathway protein localization to organelle erythrocyte homeostasis microtubule anchoring at centrosome social behavior photoreceptor cell outer segment organization negative regulation of appetite by leptin-mediated signaling pathway positive regulation of multicellular organism growth response to leptin fat cell differentiation photoreceptor cell maintenance positive regulation of cilium assembly retinal rod cell development brain morphogenesis homeostasis of number of cells sensory processing maintenance of protein location in nucleus regulation of stress fiber assembly cilium morphogenesis regulation of cilium beat frequency involved in ciliary motility face development adipose tissue development fat pad development protein localization to cilium protein localization to centrosome sperm flagellum assembly regulation of nonmotile primary cilium assembly protein localization to photoreceptor outer segment non-motile cilium assembly transport metabolic process negative regulation of GTPase activity nonmotile primary cilium assembly cilium assembly centrosome organization biological_process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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