Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MGYLRIFSPH PAKTGDGAQA EDLLLEVDLR DPVLQVEVGK FVSGTEMLHL AVLHSRKLCV YSVSGTLGNV EHGNQCQMKL MYEHNLQRTA CNMTYGSFGG VKGRDLICIQ SMDGMLMVFE QESYAFGRFL PGFLLPGPLA YSSRTDSFLT VSSCQQVESY KYQVLAFATD ADKRQETEQQ KLGSGKRLVV DWTLNIGEQA LDICIVSFNQ SASSVFVLGE RNFFCLKDNG QIRFMKKLDW SPSCFLPYCS VSEGTINTLI GNHNNMLHIY QDVTLKWATQ LPHIPVAVRV GCLQFSLWKH LLPRSSTLEK
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bardet-Biedl syndrome 9 protein; Parathyroid hormone-responsive B1 gene protein; Protein PTHB1; PTH-responsive osteosarcoma B1 protein
Gene Aliases: B1; BBS9; C18; D1; PTHB1
UniProt ID: (Human) Q3SYG4
Entrez Gene ID: (Human) 27241
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