The antibody detects endogenous levels of total BCAM / CD239 protein.
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: antigen identified by monoclonal antibody F8; AU; Auberger B antigen; B-CAM cell surface glycoprotein; B-cell adhesion molecule; Basal cell adhesion molecule; basal cell adhesion molecule (Lu and Au blood groups); basal cell adhesion molecule Lutheran blood group; CD239; F8/G253 antigen; glycoprotein 95kDa; LU; Lutheran antigen; Lutheran blood group; Lutheran blood group glycoprotein; Lutheran blood group variant LUGA; lutheran glycoprotein; MSK19
Gene Aliases: 1200005K12Rik; AU; B-CAM; BCAM; CD239; Gplu; LU; MSK19