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Invitrogen

BCL11A Polyclonal Antibody

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BCL11A Polyclonal Antibody

Product Details

PA5-114898

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human BCL11A(Accession Q9H165), corresponding to amino acid residues T180-I230.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2899534

Product Specific Information

Antibody detects endogenous levels of total BCL11A.

Target Information

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A; B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BAF chromatin remodeling complex subunit BCL11A; BCL-11A; BCL11 transcription factor A; BCL11A B-cell CLL/lymphoma 11A (zinc finger protein); BCL11A, BAF complex component; BCL11A-XS; zinc finger protein; C2H2-type zinc finger protein; COUP-TF interacting protein 1; COUP-TF-interacting protein 1; ecotropic viral integration site 9 homolog; Ecotropic viral integration site 9 protein; Ecotropic viral integration site 9 protein homolog; EVI-9; FLJ10173; FLJ34997; myeloid leukemia; unnamed protein product; Zinc finger protein 856

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Gene Aliases: 2810047E18Rik; BCL-11A; BCL11A; CTIP1; D930021L15Rik; DILOS; EVI9; Evi9a; Evi9b; Evi9c; HBFQTL5; KIAA1809; mKIAA1809; SMARCM1; ZNF856

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UniProt ID: (Human) Q9H165, (Mouse) Q9QYE3

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Entrez Gene ID: (Human) 53335, (Rat) 305589, (Mouse) 14025

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding regulatory region nucleic acid binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription cofactor activity protein binding zinc ion binding protein kinase binding protein homodimerization activity metal ion binding protein heterodimerization activity DNA-binding transcription factor binding sequence-specific double-stranded DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription corepressor activity nucleic acid binding DNA-binding transcription factor zinc finger transcription factor C2H2 zinc finger transcription factor gene-specific transcriptional regulator
Process(es)
negative regulation of transcription from RNA polymerase II promoter regulation of transcription from RNA polymerase II promoter positive regulation of gene expression positive regulation of neuron projection development negative regulation of neuron projection development protein sumoylation negative regulation of axon extension negative regulation of protein homooligomerization positive regulation of transcription from RNA polymerase II promoter negative regulation of collateral sprouting positive regulation of collateral sprouting regulation of dendrite development negative regulation of dendrite extension negative regulation of neuron remodeling cellular response to L-glutamate negative regulation of dendrite development negative regulation of branching morphogenesis of a nerve negative regulation of gene expression B cell differentiation T cell differentiation negative regulation of nucleic acid-templated transcription transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter
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