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Invitrogen
BCL2A1 Polyclonal Antibody
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Product Details
PA5-20268
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 14 amino acid peptide from near the carboxy terminus of human Bfl-1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Despite the predicted molecular weight, Bfl-1 often migrates at a higher molecular weight in SDS-PAGE, presumably due to post-translational modifications. A suggested positive control is human kidney tissue lysate.
PA5-20268 can be used with blocking peptide PEP-0383.
Target Information
Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: A1-A; alternatively spliced; Bcl-2 family member; B-cell leukemia/lymphoma 2 related protein A1a; Bcl-2 related; similar to mouse hemopoietic-specific early-response protein, Swiss-Prot Accession Number Q07440; similar to mouse transforming protein bcl-2-beta, Swiss-Prot Accession Number P10418; Method: conceptual translation supplied by author.; Bcl-2-like protein 5; Bcl-2-related protein A1; Bcl2-L-5; BCL2A1; GRS protein; hematopoietic BCL2-related protein A1; Hemopoietic-specific early response protein; Protein BFL-1; Protein GRS
Gene Aliases: A1; ACC-1; ACC-2; ACC1; ACC2; BB218357; BCL2A1; Bcl2a1a; BCL2L5; Bfl-1; BFL1; GRS; HBPA1
UniProt ID: (Human) Q16548, (Mouse) Q07440
Entrez Gene ID: (Human) 597, (Mouse) 12044
release of cytochrome c from mitochondria
apoptotic process
mitochondrial fusion
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
extrinsic apoptotic signaling pathway in absence of ligand
B cell homeostasis
negative regulation of B cell apoptotic process
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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