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Proteintech
BCL2L2 Polyclonal Antibody
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Product Details
16026-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCL2L2 Fusion Protein Ag8863 (1-171 aa encoded by BC021198)
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
30 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MATPASAPD TRALVADFVG YKLRQKGYVC GAGPGEGPAA DPLHQAMRAA GDEFETRFRR TFSDLAAQLH VTPGSAQQRF TQVSDELFQG GPNWGRLVAF FVFGAALCAE SVNKEMEPLV GQVQEWMVAY LETRLADWIH SSGGWAEFTA LYGDGALEEA RRLREGNWAS VR (1-171 aa encoded by BC021198)
Target Information
Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Apoptosis regulator Bcl-W; Bcl-2-like protein 2; Bcl2-L-2; BCL2-like 2 protein; Bcl2-like protein 2; c98; KIAA0271; protein phosphatase 1, regulatory subunit 51; unnamed protein product
Gene Aliases: AW048834; BCL-W; BCL-WEL; BCL-WS; BCL2-L-2; BCL2L2; BCLW; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51
UniProt ID: (Human) Q92843, (Mouse) P70345
Entrez Gene ID: (Human) 599, (Mouse) 12050, (Rat) 60434
release of cytochrome c from mitochondria
developmental process involved in reproduction
apoptotic process
spermatogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of apoptotic process
positive regulation of apoptotic process
negative regulation of apoptotic process
transmembrane transport
Sertoli cell proliferation
extrinsic apoptotic signaling pathway in absence of ligand
negative regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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