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Proteintech
BCL6 Polyclonal Antibody
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Product Details
21187-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCL6 Fusion Protein Ag15519 (183-532 aa encoded by BC150184)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SLYSGLSTP PASYSMYSHL PVSSLLFSDE EFRDVRMPVA NPFPKERALP CDSARPVPGE YSRPTLEVSP NVCHSNIYSP KETIPEEARS DMHYSVAEGL KPAAPSARNA PYFPCDKASK EEERPSSEDE IALHFEPPNA PLNRKGLVSP QSPQKSDCQP NSPTESCSSK NACILQASGS PPAKSPTDPK ACNWKKYKFI VLNSLNQNAK PEGPEQAELG RLSPRAYTAP PACQPPMEPE NLDLQSPTKL SASGEDSTIP QASRLNNIVN RSMTGSPRSS SESHSPLYMH PPKCTSCGSQ SPQHAEMCLH TAGPTFPEEM GETQSEYSDS SCENGAFFCN ECDCRFSEEA S (183-532 aa encoded by BC150184)
Target Information
Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S
Gene Aliases: BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51
UniProt ID: (Human) P41182
Entrez Gene ID: (Human) 604
RNA polymerase II regulatory region sequence-specific DNA binding
intronic transcription regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
chromatin DNA binding
sequence-specific DNA binding
metal ion binding
C2H2 zinc finger transcription factor
protein import into nucleus, translocation
negative regulation of transcription from RNA polymerase II promoter
cell morphogenesis
negative regulation of cell-matrix adhesion
germinal center formation
regulation of germinal center formation
negative regulation of B cell apoptotic process
transcription, DNA-templated
inflammatory response
cellular response to DNA damage stimulus
Rho protein signal transduction
spermatogenesis
negative regulation of cell proliferation
actin cytoskeleton organization
myeloid cell differentiation
B cell differentiation
negative regulation of cell growth
positive regulation of B cell proliferation
positive regulation of histone deacetylation
negative regulation of mast cell cytokine production
negative regulation of Rho protein signal transduction
type 2 immune response
regulation of cell proliferation
regulation of apoptotic process
positive regulation of apoptotic process
regulation of GTPase activity
regulation of memory T cell differentiation
negative regulation of T-helper 2 cell differentiation
positive regulation of neuron differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
negative regulation of isotype switching to IgE isotypes
erythrocyte development
regulation of inflammatory response
regulation of neurogenesis
regulation of immune response
positive regulation of cellular component movement
negative regulation of cellular senescence
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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