Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request:org.apache.struts2.dispatcher.StrutsRequestWrapper@12a8de66
Request attributes: pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

Invitrogen

BCL6 Polyclonal Antibody

View all (68) BCL6 antibodies
Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-96599

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 -

Immunocytochemistry (ICC/IF)

 1:50 - 1:100 -
Product Specifications

Species Reactivity

 Human, Mouse, Rat

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

A synthetic peptide corresponding to amino acids 350-450 of human BCL6.
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 2.16 mg/mL

Purification

 Affinity Chromatography

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.05% ProClin 300

Storage conditions

 -20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2808401

Product Specific Information

Immunogen sequence: MASPADSCIQ FTRHASDVLL NLNRLRSRDI LTDVVIVVSR EQFRAHKTVL MACSGLFYSI FTDQLKCNLS VINLDPEINP EGFCILLDFM YTSRLNLREG NIMAVMATAM YLQMEHVVDT CRKFIKASEA EMVSAIKPPR EEFLNSRMLM PQDIMAYRGR EVVENNLPLR SAPGCESRAF APSLYSGLST PPASYSMYSH LPVSSLLFSD EEFRDVRMPV ANPFPKERAL PCDSARPVPG EYSRPTLEVS PNVCHSNIYS PKETIPEEAR SDMHYSVAEG; Positive Samples: Raji, Jurkat, Mouse lung; Cellular Location: Nucleus

Target Information

Bcl-6 proto-oncogene product (a Kruppel-type zinc-finger protein) is mainly expressed in normal germinal center B cells and related lymphomas. Bcl-6 is involved in chromosome rearrangements at 3q27 in non-Hodgkin's lymphomas and Bcl-6 rearrangements have been detected in 33%-45% of diffuse large B cell lymphomas. Bcl-6 has been detected immunohistochemically in follicular lymphomas, diffuse large B cell lymphomas, Burkitt's lymphomas and in nodular, lymphocyte predominant Hodgkin's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: B-cell leukemia/lymphoma 5; B-cell leukemia/lymphoma 6; B-cell lymphoma 5 protein; B-cell lymphoma 5 protein (BCL5); B-cell lymphoma 6 protein; B-cell lymphoma 6 protein homolog; B-cell lymphoma 6 protein transcript; BCL-5; BCL-6; cys his2 zinc finger transcription factor; cys-his2 zinc finger transcription factor; LAZ-3 protein; Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3); lymphoma-associated zinc finger gene on chromosome 3; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger and BTB domain-containing protein 27 (ZBTB27); Zinc finger protein 51; Zinc Finger Protein 51 (ZNF51); zinc finger transcription factor BCL6S

Gene Aliases: Bcl-6; BCL5; BCL6; BCL6A; LAZ3; ZBTB27; ZNF51

UniProt ID: (Human) P41182, (Mouse) P41183

Entrez Gene ID: (Human) 604, (Rat) 303836, (Mouse) 12053

Molecular Function: C2H2 zinc finger transcription factor

Function(s)
protein import into nucleus, translocation negative regulation of transcription from RNA polymerase II promoter cell morphogenesis negative regulation of cell-matrix adhesion germinal center formation regulation of germinal center formation negative regulation of B cell apoptotic process transcription, DNA-templated inflammatory response cellular response to DNA damage stimulus Rho protein signal transduction spermatogenesis negative regulation of cell proliferation actin cytoskeleton organization myeloid cell differentiation B cell differentiation negative regulation of cell growth positive regulation of B cell proliferation positive regulation of histone deacetylation negative regulation of mast cell cytokine production negative regulation of Rho protein signal transduction type 2 immune response regulation of cell proliferation regulation of apoptotic process positive regulation of apoptotic process regulation of GTPase activity regulation of memory T cell differentiation negative regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of Notch signaling pathway negative regulation of transcription, DNA-templated negative regulation of isotype switching to IgE isotypes erythrocyte development regulation of inflammatory response regulation of neurogenesis regulation of immune response positive regulation of cellular component movement negative regulation of cellular senescence negative regulation of type 2 immune response regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter protein localization biological_process negative regulation of apoptotic process negative regulation of cell differentiation immune system process regulation of transcription, DNA-templated
Process(es)
RNA polymerase II regulatory region sequence-specific DNA binding intronic transcription regulatory region sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding chromatin binding transcription factor activity, sequence-specific DNA binding protein binding chromatin DNA binding sequence-specific DNA binding metal ion binding molecular_function DNA binding nucleic acid binding
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support
Display Info:
cookie.CK_ISO_CODE.value:us
cookie.CK_LANG_CODE.value:en
cookie.CK_DISPLAY_TYPE.value:
pageContext.request.scheme:http(not used)
syndicationProtocol:https
syndicationExtensionPrefix:
syndicationDisplayType:

© Copyright 2006-2022 Thermo Fisher Scientific Inc. All rights reserved