This Antibody was verified by KnockDown to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: QKSPEIHRRI DISPSTLRKH TRLAGEERVF KEENQKGDKK LRCDSADLRH DIDRRRKERS KERGDSKGSR ESSGSRKQEK TPKDYKEYKS YKDDSKHKRE QDHSRSSSSS ASPSSPSSR
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 95%.
BCLAF1 is an intracellular, death promoting transcriptional repressor of survival genes that interacts with several members of the BCL2 family of proteins. It shows homology to the basic leucine zipper (bzip) and MYB DNA binding domains. From recent research it can be concluded that in case of apoptotic cells this protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope. When over expressed this protein induces apoptosis and can be suppressed by co-expression of BCL2 proteins. Also known as BTF, it triggers a proapoptotic signal, potentially helpful to overcome the resistance to STI571. BCLAF1 is found to express mostly in skeletal muscles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; BCLAF1 and THRAP3 family member 1; bK211L9.1; BTF
Gene Aliases: BCLAF1; bK211L9.1; BTF; KIAA0164
UniProt ID: (Human) E1P586
Entrez Gene ID: (Human) 9774
Molecular Function: transcription factor