Positive Control: K562, K562 nuclear extract
Predicted Reactivity: Pig (96%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
BTF encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; BCLAF1; BCLAF1 and THRAP3 family member 1; bK211L9.1; Btf
Gene Aliases: 2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; Aa2-041; AI450190; AW556225; BCLAF1; bK211L9.1; BTF; KIAA0164; mKIAA0164
Molecular Function: transcription factor