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Invitrogen
BCOR Polyclonal Antibody
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Product Details
PA5-106545
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human BCOR(Accession Q6W2J9), corresponding to amino acid residues V1237-F1287.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total BCOR.
Target Information
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BCL-6 coreceptor; BCL-6 corepressor; BCL-6 interacting corepressor; BCL6 interacting corepressor; BCoR; transcriptional corepressor; unnamed protein product
Gene Aliases: 5830466J11Rik; 8430401K06Rik; ANOP2; BCOR; BcorR; D930024N20Rik; KIAA1575; MAA2; MCOPS2; mKIAA1575
UniProt ID: (Human) Q6W2J9, (Mouse) Q8CGN4
Entrez Gene ID: (Human) 54880, (Mouse) 71458
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcription corepressor activity
ubiquitin-protein transferase activity
protein binding
heat shock protein binding
histone deacetylase binding
DNA-binding transcription factor binding
transcription factor binding
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
blastocyst hatching
chromatin organization
chromatin remodeling
heart development
negative regulation of bone mineralization
odontogenesis
negative regulation of transcription, DNA-templated
palate development
specification of axis polarity
negative regulation of tooth mineralization
negative regulation of histone H3-K36 methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
chromatin modification
histone H2A monoubiquitination
negative regulation of histone H3-K4 methylation
negative regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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