FIGURE: 1 / 1
Immunogen sequence: LRVDRKRKVS GDSSHTETTA EEVPEDPLLK AKRRRVSKDD WPEREMTNSS SNHLEDPHYS ELTNLKVCIE LTGLHPKKQR HLLHLRERWE QQVSAADGKP G
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: BCL-6 corepressor; BCL-6 interacting corepressor; BCoR
Gene Aliases: ANOP2; BCOR; KIAA1575; MAA2; MCOPS2
UniProt ID: (Human) Q6W2J9
Entrez Gene ID: (Human) 54880