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Product Details
22585-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCR Fusion Protein Ag18281 (1-350 aa encoded by BC066122)
Conjugate
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVDPVGFAE AWKAQFPDSE PPRMELRSVG DIEQELERCK ASIRRLEQEV NQERFRMIYL QTLLAKEKKS YDRQRWGFRR AAQAPDGASE PRASASRPQP APADGADPPP AEEPEARPDG EGSPGKARPG TARRPGAAAS GERDDRGPPA SVAALRSNFE RIRKGHGQPG ADAEKPFYVN VEFHHERGLV KVNDKEVSDR ISSLGSQAMQ MERKKSQHGA GSSVGDASRP PYRGRSSESS CGVDGDYEDA ELNPRFLKDN LIDANGGSRP PWPPLEYQPY QSIYVGGMME GEGKGPLLRS QSTSEQEKRL TWPRRSYSPR SFEDCGGGYT PDCSSNENLT SSEEDFSSGQ S (1-350 aa encoded by BC066122)
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABL; BCR protein; bcr/abl; BCR/FGFR1 chimera protein; breakpoint cluster region; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; v-abl
Gene Aliases: ALL; BCR; BCR1; CML; D22S11; D22S662; PHL
UniProt ID: (Human) P11274
Entrez Gene ID: (Human) 613
negative regulation of cellular extravasation
protein phosphorylation
signal transduction
brain development
peptidyl-tyrosine phosphorylation
actin cytoskeleton organization
response to lipopolysaccharide
regulation of Rho protein signal transduction
intracellular signal transduction
inner ear morphogenesis
regulation of vascular permeability
negative regulation of neutrophil degranulation
positive regulation of GTPase activity
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
negative regulation of inflammatory response
positive regulation of phagocytosis
neuromuscular process controlling balance
regulation of small GTPase mediated signal transduction
regulation of cell cycle
negative regulation of blood vessel remodeling
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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