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Invitrogen
BCR Polyclonal Antibody
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FIGURE: 1 / 4
BCR Antibody (PA5-17709) in ICC/IF
Immunofluorescence analysis of BCR was performed using K-562 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with BCR Polyclonal Antibody (Product # PA5-17709) at 1:250 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034) at a dilution of 1:2000 ... View More
Product Details
PA5-17709
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the amino-terminal sequence of human Bcr
Conjugate
Form
Liquid
Concentration
526 µg/mL
Amount
52.6 µg
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABL; bcr; BCR protein; BCR, RhoGEF and GTPase activating protein; bcr/abl; bcr/able fusion protein; BCR/FGFR1 chimera protein; breakpoint cluster region; breakpoint cluster region homolog; Breakpoint cluster region protein; c-ABL; c-abl oncogene 1; EC 2.7.11.1; FGFR1/BCR chimera protein; JTK7; p150; protein kinase; Renal carcinoma antigen NY-REN-26; RP11-83J21.1; unnamed protein product; v-abl
Gene Aliases: 5133400C09Rik; AI561783; AI853148; ALL; BCR; BCR1; CML; D22S11; D22S662; Kiaa3017; mKIAA3017; PHL
UniProt ID: (Human) P11274, (Rat) F1LXF1, (Mouse) Q6PAJ1
Entrez Gene ID: (Pig) 100157974, (Human) 613, (Rat) 309696, (Mouse) 110279
nucleotide binding
protein serine/threonine kinase activity
protein tyrosine kinase activity
guanyl-nucleotide exchange factor activity
GTPase activator activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
Rho guanyl-nucleotide exchange factor activity
enzyme binding
G-protein modulator
negative regulation of cellular extravasation
renal system process
protein phosphorylation
phagocytosis
signal transduction
small GTPase mediated signal transduction
brain development
cell migration
actin cytoskeleton organization
keratinocyte differentiation
response to lipopolysaccharide
regulation of Rho protein signal transduction
intracellular signal transduction
inner ear morphogenesis
regulation of vascular permeability
neutrophil degranulation
negative regulation of neutrophil degranulation
focal adhesion assembly
homeostasis of number of cells
negative regulation of inflammatory response
positive regulation of phagocytosis
modulation of synaptic transmission
neuromuscular process controlling balance
regulation of small GTPase mediated signal transduction
establishment of localization in cell
regulation of cell cycle
definitive hemopoiesis
negative regulation of respiratory burst
negative regulation of blood vessel remodeling
intracellular protein transmembrane transport
cellular response to lipopolysaccharide
activation of GTPase activity
macrophage migration
negative regulation of macrophage migration
negative regulation of reactive oxygen species metabolic process
negative regulation of cell migration
positive regulation of GTPase activity
protein autophosphorylation
platelet-derived growth factor receptor signaling pathway
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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