PA5-29334 targets Bcr in IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-29334 immunogen is recombinant fragment corresponding to a region within amino acids 907 and 1231 of Human Bcr.
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A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: ALL; BCR/FGFR1 chimera protein; BCR1; breakpoint cluster region; Breakpoint cluster region protein; CML; D22S11; D22S662; FGFR1/BCR chimera protein; PHL; Renal carcinoma antigen NY-REN-26
Gene Aliases: ALL; BCR; BCR1; CML; D22S11; D22S662; PHL
UniProt ID: (Human) P78501
Entrez Gene ID: (Human) 613