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Proteintech
BCRP/ABCG2 Polyclonal Antibody
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Product Details
27286-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCRP/ABCG2 fusion protein Ag25911
Conjugate
Form
Liquid
Concentration
600 µg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: NLTTIASWLS WLQYFSIPRY GFTALQHNEF LGQNFCPGLN ATGNNPCNYA TCTGEEYLVK QGIDLSPWGL WKNH
Target Information
ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter; ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); Breast cancer resistance protein; Breast cancer resistance protein 1 homolog; Broad substrate specificity ATP-binding cassette transporter ABCG2; CD338; CDw338; mitoxantrone resistance protein 1; Mitoxantrone resistance-associated protein; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; Urate exporter
Gene Aliases: ABC15; ABCG2; ABCP; AI428558; BCRP; BCRP1; BMDP; CD338; CDw338; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
UniProt ID: (Human) Q9UNQ0, (Mouse) Q7TMS5
Entrez Gene ID: (Human) 9429, (Mouse) 26357
transporter activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
heme transporter activity
ATPase activity, coupled to transmembrane movement of substances
protein homodimerization activity
nucleotide binding
drug transmembrane transporter activity
ATPase activity
protein dimerization activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
transport
drug transmembrane transport
cellular iron ion homeostasis
response to iron ion
heme transport
response to drug
xenobiotic transport
urate metabolic process
drug export
response to folic acid
embryonic process involved in female pregnancy
cellular response to dexamethasone stimulus
drug transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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