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Proteintech
BCRP/ABCG2 Polyclonal Antibody
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Product Details
27286-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BCRP/ABCG2 fusion protein Ag25911
Conjugate
Form
Liquid
Concentration
600 µg/mL
Amount
90 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: NLTTIASWLS WLQYFSIPRY GFTALQHNEF LGQNFCPGLN ATGNNPCNYA TCTGEEYLVK QGIDLSPWGL WKNH
Target Information
ABCG2, is also known as placenta-specific ABC transporter and breast cancer resistance protein (BCRP1). ABCG2 confers resistance for a variety of chemotherapeutic agents, including anthracyclines, mitoxantrone, bisantrene and topotecan. Under normal conditions, ABCG2 may serve a protective function by removing toxins from the cell, and plays an important role in regulating stem cell differentiation. ABCG2 is responsible for the side population (SP) phenotype and is widely expressed in a large variety of stem cells, making it an important stem cell marker. ABCG2 may have N-linked glycosylation and may dimerize in vivo. ABCG2 is abundantly expressed in placenta, liver, intestine and stem cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ABC transporter; ABCG2; ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette sub-family G member 2; ATP-binding cassette transporter; ATP-binding cassette transporter G2; ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group); ATPbinding cassette transporter ABCG2; Breast cancer resistance protein; Breast cancer resistance protein 1 homolog; Broad substrate specificity ATP-binding cassette transporter ABCG2; broad substrate specificity ATP-binding cassette transporter ABCG2 isoform 1 (Junior blood group); CD338; CDw338; mitoxantrone resistance protein 1; Mitoxantrone resistance-associated protein; multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2; placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; transporter; unnamed protein product; Urate exporter
Gene Aliases: ABC15; ABCG2; ABCP; AI428558; BCRP; BCRP1; BMDP; CD338; CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1; UAQTL1
UniProt ID: (Human) Q9UNQ0, (Mouse) Q7TMS5
Entrez Gene ID: (Human) 9429, (Mouse) 26357
nucleotide binding
protein binding
ATP binding
organic anion transmembrane transporter activity
xenobiotic-transporting ATPase activity
urate transmembrane transporter activity
biotin transporter activity
efflux transmembrane transporter activity
ATPase activity
riboflavin transporter activity
ATPase activity, coupled to transmembrane movement of substances
identical protein binding
protein homodimerization activity
xenobiotic transporter activity
sphingolipid transporter activity
protein dimerization activity
ABC-type transporter activity
drug transmembrane transporter activity
ATP-binding cassette (ABC) transporter
primary active transporter
transporter
lipid transport
organic anion transport
urate transport
biotin transport
sphingolipid biosynthetic process
riboflavin transport
urate metabolic process
transmembrane transport
transepithelial transport
urate salt excretion
export across plasma membrane
transport across blood-brain barrier
cellular detoxification
drug transport across blood-brain barrier
transport
drug transmembrane transport
drug transport
drug export
embryonic process involved in female pregnancy
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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