This gene encodes a member of the short-chain dehydrogenase/reductase gene family. The encoded protein forms a homotetrameric lipid-requiring enzyme of the mitochondrial membrane and has a specific requirement for phosphatidylcholine for optimal enzymatic activity. The encoded protein catalyzes the interconversion of acetoacetate and -3-hydroxybutyrate, the two major ketone bodies produced during fatty acid catabolism. Alternatively spliced transcript variants encoding the same protein have been described.
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Protein Aliases: (R)-3-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase; 3-hydroxybutyrate dehydrogenase (heart, mitochondrial); b-hydroxybutyrate dehydrogenase; BDH; D-beta-hydroxybutyrate dehydrogenase, mitochondrial; MGC2723; MGC4347; MGC9788; Short chain dehydrogenase/reductase family 9C member 1; short chain dehydrogenase/reductase family 9C, member 1
Gene Aliases: 2310032J20Rik; AI327223; BDH; BDH1; SDR9C1