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|Tested species reactivity||Human, Mouse, Rat|
|Published species reactivity||Mouse|
|Host / Isotype||Sheep / IgG|
|Immunogen||Recombinant human BDNF.|
|Storage buffer||whole serum|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Inhibition Assays (IA)||1:10-1:50|
|Western Blot (WB)||1:200-1:2000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Immunohistochemistry (IHC)||See 1 publications below|
PA1-18364 detects BDNF from human and rat samples.
PA1-18364 has been successfully used in immunohistochemistry, ELISA, Western blot, and inhibition assay procedures.
The PA1-18364 immunogen is recombinant human BDNF.
Reconstitute with 100 ul of distilled water. Glycerol (1:1) may be added for additional stability.
The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bacterial infection causes stress-induced memory dysfunction in mice.
PA1-18364 was used in immunohistochemistry to investigate the effect of enteric bacterial infections on stress-associated behaviour in mice
|Gareau MG,Wine E,Rodrigues DM,Cho JH,Whary MT,Philpott DJ,Macqueen G,Sherman PM||Gut (60:307)||2011|
abrineurin; anorexia BDNF; brain derived neurothrophic factor; brain derived neurotrophic factor; brain-derived neurotrophic factor; neurotrophin
ANON2; BDNF; BULN2