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Invitrogen
BEND2 Polyclonal Antibody
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Product Details
PA5-53022
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human BEND2. Recombinant protein control fragment (Product #RP-92245).
Conjugate
Form
Liquid
Concentration
0.10 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DQDDASASAC LTPDFALLPL NILVKVDTNT ENSVNTMNRS TLLDSDSGQD SSSSSVCIPP KYGYLGDPKR NVRVLKIHLL AVQNMAKPKQ AACYLVRILF SKEILISSSV DIHLKDSQSL DPNKMAALRE YLATTFPTCD LHEHG
Highest antigen sequence identity to the following orthologs: Mouse - 32%, Rat - 21%.
Target Information
The BEND2 gene, located on chromosome Xp22.2, encodes a protein that is part of the BEN domain-containing family, which is implicated in chromatin organization and transcriptional regulation. BEND2 is critical in spermatogenesis, particularly in the meiotic phase of germ cell development. Knockout studies in male mice have shown that loss of BEND2 disrupts the transition from zygonema to pachynema, interferes with chromosomal synapsis, and impairs the repair of DNA double-strand breaks, ultimately causing infertility. Additionally, BEND2's interaction with chromatin-associated proteins suggests its role in the formation of transcription-repressor complexes, essential for proper gene expression regulation during meiosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BEN domain-containing protein 2
Gene Aliases: BEND2; CXorf20
UniProt ID: (Human) Q8NDZ0
Entrez Gene ID: (Human) 139105
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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