Immunogen sequence: TQRQGQEHIG SSCSFAEQAL RLGSAPEVLL VRKHMRERLA ALAAQAFPER PHENAQLELV LEVDGLRRSV LNLGALLTTS ATAHETVAT
The protein encoded by this gene is a member of the tripartite motif family, also called the 'RING-B-box-coiled-coil' subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified.
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Protein Aliases: brain expressed ring finger; Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97; tripartite motif protein TRIM3; tripartite motif-containing 3; Tripartite motif-containing protein 3
Gene Aliases: BERP; HAC1; RNF22; RNF97; TRIM3
UniProt ID: (Human) O75382
Entrez Gene ID: (Human) 10612
Molecular Function: ubiquitin-protein ligase