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Product Details
12390-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BEX1/2 Fusion Protein Ag3066 (1-128 aa encoded by BC015522)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody detects both BEX1 and BEX2.
Immunogen sequence: MESKEERAL NNLIVENVNQ ENDEKDEKEQ VANKGEPLAL PLNVSEYCVP RGNRRRFRVR QPILQYRWDI MHRLGEPQAR MREENMERIG EEVRQLMEKL REKQLSHSLR AVSTDPPHHD HHDEFCLMP (1-128 aa encoded by BC015522 )
Target Information
BEX1/BEX2 belongs to the brain expressed X-linked gene family. The encoded protein interacts with the transcription factor LIM domain only 2 in a DNA-binding complex that recognizes the E-box element and promotes transcription. BEX1/BEX2 has been found to be a tumor suppressor that is silenced in human glioma. In breast cancer cells, this gene product modulates apoptosis in response to estrogen and tamoxifen, and enhances the anti-proliferative effect of tamoxifen. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: brain expressed gene 1; brain expressed, X-linked 1; Brain-expressed X-linked protein 1; Brain-expressed X-linked protein 1 homolog; Brain-expressed X-linked protein 2; Brain-expressed X-linked protein 2 homolog; EG2RVC; expression gene 2 in rat visual cortex; hBex2; ovarian granulosa cell 13.0 kDa protein hGR74; Protein BEX1; Protein BEX2; protein hBex2; reduced expression 3; Reduced expression protein 3; REX-3
Gene Aliases: AA407839; AL024066; AU018692; BEX1; BEX2; Bex4; DJ79P11.1; EG2RVC; HBEX2; HGR74-h; Rex3
UniProt ID: (Human) Q9HBH7, (Human) Q9BXY8, (Mouse) Q9R224, (Rat) Q3MKQ2, (Rat) Q3MKQ1, (Mouse) Q9WTZ8
Entrez Gene ID: (Human) 55859, (Human) 84707, (Mouse) 19716, (Rat) 501625, (Rat) 363498, (Mouse) 12069
positive regulation of neuroblast proliferation
multicellular organism development
nervous system development
cell differentiation
negative regulation of neuron differentiation
neurotrophin TRK receptor signaling pathway
apoptotic process
regulation of apoptotic process
regulation of cell cycle
cell cycle
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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