Immunogen sequence: GRRFTMGERI GAIKQESEEP PTKKNRMQLS DDEGHFTSSD LISSPFLGPH PHQPPFCLPF YLIPPSATAY LPMLEKCWYP TSVPVLYPGL NASAAALSSF MNPDKISAPL LMPQRLPSPL PAHPSVDSSV LLQ
Differentiated embryo-chondrocyte expressed gene 1 (DEC1) is an important protein involved in embryonic cell differentiation, proliferation, and apoptosis. It has also recently been shown to be regulated by hypoxia. The loss of DEC1 expression may be an early event in the development of lung cancer, while DEC1 may be up-regulated by hypoxia in other cancers and in more extreme hypoxia it may have a role in cell death.
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Protein Aliases: basic helix-loop-helix domain containing, class B, 2; basic helix-loop-helix family, member e40; BHLHB2; bHLHe40; Class B basic helix-loop-helix protein 2; Class E basic helix-loop-helix protein 40; DEC1; differentially expressed in chondrocytes 1; Differentially expressed in chondrocytes protein 1; differentiated embryo chondrocyte expressed gene 1; Enhancer-of-split and hairy-related protein 2; SHARP-2; Stimulated by retinoic acid gene 13 protein; STRA13
Gene Aliases: BHLHB2; BHLHE40; DEC1; HLHB2; SHARP-2; SHARP2; STRA13; Stra14
UniProt ID: (Human) O14503
Entrez Gene ID: (Human) 8553