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Bethyl Laboratories
BID Polyclonal Antibody
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Product Details
IHC-00121
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 60 and 120 of human BH3 interacting domain death agonist.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee and Northern white-cheeked gibbon
Target Information
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: apoptic d; apoptic death agonist; BH3-interacting domain death agonist; BID; desmocollin type 4; HGNC:1050; Human BID coding sequence; MGC15319; MGC42355; OTTHUMP00000196197; p22 BID; unnamed protein product
Gene Aliases: BID; FP497
UniProt ID: (Human) P55957
Entrez Gene ID: (Human) 637
release of cytochrome c from mitochondria
protein targeting to mitochondrion
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
apoptotic mitochondrial changes
positive regulation of mitochondrial membrane potential
positive regulation of protein complex assembly
cellular response to stress
intracellular signal transduction
regulation of T cell proliferation
signal transduction in response to DNA damage
mitochondrial ATP synthesis coupled electron transport
regulation of apoptotic process
positive regulation of apoptotic process
regulation of epithelial cell proliferation
neuron apoptotic process
protein-containing complex assembly
establishment of protein localization to membrane
positive regulation of release of cytochrome c from mitochondria
extrinsic apoptotic signaling pathway
hepatocyte apoptotic process
mitochondrial outer membrane permeabilization
fibril organization
regulation of mitochondrial membrane permeability involved in apoptotic process
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
regulation of intracellular signal transduction
regulation of G1/S transition of mitotic cell cycle
positive regulation of fibroblast apoptotic process
regulation of apoptotic signaling pathway
positive regulation of apoptotic signaling pathway
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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