Immunogen sequence: HHHHLLQDAY MQQYQHATQQ QQMLQQQFLM HSVYQPQPSA SQYPTMMPQY QQAFFQQQML AQHQPSQQQA SPEYLTSPQE FSPALVSYTS SLPAQV
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.
This gene is the human homolog of mouse BMP-2-inducible kinase. Bone morphogenic proteins play a key role in skeletal development and patterning. Expression of the mouse gene is increased during BMP-2 induced differentiation and the gene product is a putative serine/threonine protein kinase containing a nuclear localization signal. Therefore, the protein encoded by this human homolog is thought to be a protein kinase with a putative regulatory role in attenuating the program of osteoblast differentiation. Two transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: BIKE; Bike kinase; BMP-2 inducible kinase; BMP-2-inducible protein kinase; BMP2 inducible kinase; BMP2K; HRIHFB2017
Gene Aliases: BIKE; BMP2K; HRIHFB2017
UniProt ID: (Human) Q9NSY1
Entrez Gene ID: (Human) 55589