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Proteintech
BIN1 Polyclonal Antibody
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Product Details
14647-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BIN1 Fusion Protein Ag6240 (1-439 aa encoded by BC004101)
Conjugate
Form
Liquid
Concentration
0.44 mg/mL
Amount
66 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAEMGSKGV TAGKIASNVQ KKLTRAQEKV LQKLGKADET KDEQFEQCVQ NFNKQLTEGT RLQKDLRTYL ASVKAMHEAS KKLNECLQEV YEPDWPGRDE ANKIAENNDL LWMDYHQKLV DQALLTMDTY LGQFPDIKSR IAKRGRKLVD YDSARHHYES LQTAKKKDEA KIAKAEEELI KAQKVFEEMN VDLQEELPSL WNSRVGFYVN TFQSIAGLEE NFHKEMSKLN QNLNDVLVGL EKQHGSNTFT VKAQPSDNAP AKGNKSPSPP DGSPAATPEI RVNHEPEPAG GATPGATLPK SPSQPAEASE VAGGTQPAAG AQEPGETAAS EAASSSLPAV VVETFPATVN GTVEGGSGAG RLDLPPGFMF KVQAQHDYTA TDTDELQLRA GDVVLVIPFQ NPEEQDEGWL MGVKESDWNQ HKELEKCRGV FPENFTERVP (1-439 aa encoded by BC004101)
Target Information
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPH 2; Amph2; amphiphysin 2; amphiphysin I homolog; Amphiphysin II; amphiphysin IIamph2; amphiphysin isoform II; subtype 2; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; myc box dependent interacting protein 1; Myc box-dependent-interacting protein 1; SH3 domain-containing protein 9; unnamed protein product
Gene Aliases: ALP-1; AMPH2; AMPHL; BIN1; BRAMP-2; CNM2; SH3P9
UniProt ID: (Human) O00297, (Mouse) O08539, (Rat) O08839
Entrez Gene ID: (Human) 274, (Mouse) 30948, (Rat) 117028
protease binding
protein binding
phospholipid binding
lipid binding
aspartic-type endopeptidase inhibitor activity
clathrin binding
identical protein binding
macromolecular complex binding
tau protein binding
actin filament binding
GTPase binding
chaperone binding
RNA polymerase binding
protein complex binding
protein heterodimerization activity
endocytosis
multicellular organism development
regulation of endocytosis
cell differentiation
muscle cell differentiation
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of neuron differentiation
positive regulation of endocytosis
positive regulation of astrocyte differentiation
lipid tube assembly
regulation of cell cycle arrest
negative regulation of transcription from RNA polymerase II promoter
nucleus organization
cytoskeleton organization
endosome to lysosome transport
regulation of cell cycle process
positive regulation of actin filament polymerization
T-tubule organization
synaptic vesicle endocytosis
establishment of localization in cell
regulation of heart rate by cardiac conduction
negative regulation of potassium ion transmembrane transport
negative regulation of beta-amyloid formation
negative regulation of ventricular cardiac muscle cell action potential
negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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