PA5-28921 targets BIN1 in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28921 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 289 of Human BIN1.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial. For short-term storage (1-2 weeks), product can be stored at 4°C. For long-term storage, aliquot and store product at -20° C or below, avioiding multiple freeze-thaw cycles.
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynanim, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
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Protein Aliases: AMPH2; Amphiphysin II; Amphiphysin-like protein; AMPHL; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; Myc box-dependent-interacting protein 1; SH3P9
Gene Aliases: AMPH2; AMPHL; BIN1; SH3P9
UniProt ID: (Human) O00499
Entrez Gene ID: (Human) 274