This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
Immunogen sequence: VTAGKIASNV QKKLTRAQEK VLQKLGKADE TKDEQFEQCV QNFNKQLTEG TRLQKDLRTY LASVKAMHEA SKKLNECLQE VYEPDWPGRD EANKIAENND LLWMDYHQKL VDQALLTMDT YLGQFPDIKS RIAKRGRKLV DYDSARHH
This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AMPH 2; Amphiphysin II; amphiphysin-like; Amphiphysin-like protein; box dependant MYC interacting protein 1; Box-dependent myc-interacting protein 1; Bridging integrator 1; DKFZp547F068; MGC10367; MGC105358; Myc box-dependent-interacting protein 1
Gene Aliases: AMPH2; AMPHL; BIN1; SH3P9
UniProt ID: (Human) O00499
Entrez Gene ID: (Human) 274