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Proteintech
BIRC8 Polyclonal Antibody
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Product Details
20144-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BIRC8 Fusion Protein Ag13658 (1-236 aa encoded by BC039318)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTGYEARLI TFGTWMYSVN KEQLARAGFY AIGQEDKVQC FHCGGGLANW KPKEDPWEQH AKWYPGCKYL LEEKGHEYIN NIHLTRSLEG ALVQTTKKTP SLTKRISDTI FPNPMLQEAI RMGFDFKDVK KIMEERIQTS GSNYKTLGVL VADLVSAQKD TTENELNQTS LQREISPEEP LRRLQEEKLC KICMDRHIAV VFIPCGHLVT CKQCAEAVDR CPMCSMVIDF KQRVFMS (1-236 aa encoded by BC039318)
Target Information
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Gene Aliases: hILP2; ILP-2; ILP2; RNF136
Entrez Gene ID: (Human) 112401
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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