Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2. ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.
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Protein Aliases: baculoviral IAP repeat-containing 8; Baculoviral IAP repeat-containing protein 4; Baculoviral IAP repeat-containing protein 8; BIRC8; E3 ubiquitin-protein ligase XIAP; hILP2; IAP homolog A; IAP like protein 2; IAP-3; IAP-like protein 2; ILP 2; ILP2; Inhibitor of apoptosis protein 3; Inhibitor of apoptosis-like protein 2; RING-type E3 ubiquitin transferase XIAP; Testis-specific inhibitor of apoptosis; X-linked IAP; X-linked inhibitor of apoptosis protein
Gene Aliases: 1110015C02Rik; Aipa; Api3; Birc4; BIRC8; hILP2; IAP3; ILP-1; ILP-2; ILP2; MIHA; Xiap