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Fabgennix
BLK Polyclonal Antibody
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Product Details
BLK-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Tyrosine-protein kinase BLK Protein
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase that belongs to the Src family of kinases. BLK plays an important role in B-cell activation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; MGC10442; p55-Blk; Tyrosine-protein kinase Blk
Gene Aliases: BLK; MODY11
UniProt ID: (Human) P51451, (Mouse) P16277
Entrez Gene ID: (Human) 640, (Mouse) 12143, (Rat) 364403
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
kinase modulator
cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
positive regulation of insulin secretion
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of apoptotic process
innate immune response
regulation of phagocytosis
B cell receptor signaling pathway
regulation of podosome assembly
protein phosphorylation
phosphorylation
peptidyl-tyrosine phosphorylation
T cell differentiation
cellular response to peptide hormone stimulus
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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