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Product Details
PA5-77879
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human BLK. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
2.21 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 0.1M glycine, 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2735528
Product Specific Information
Positive Control: Jurkat, Raji
Predicted Reactivity: Mouse (96%), Rat (96%), Zebrafish (81%), Bovine (95%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
B-lymphoid tyrosine kinase (BLK) is a non-receptor tyrosine kinase that belongs to the Src family of kinases. BLK plays an important role in B-cell activation. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B lymphocyte kinase; B lymphoid tyrosine kinase; BLK nonreceptor tyrosine kinase; MGC10442; p55-Blk; Tyrosine-protein kinase Blk
Gene Aliases: BLK; MODY11
UniProt ID: (Human) P51451
Entrez Gene ID: (Human) 640
cytoskeleton organization
transmembrane receptor protein tyrosine kinase signaling pathway
cell differentiation
positive regulation of insulin secretion
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
negative regulation of apoptotic process
innate immune response
regulation of phagocytosis
B cell receptor signaling pathway
regulation of podosome assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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