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Bethyl Laboratories

BLM Polyclonal Antibody

View all (25) Blooms Syndrome antibodies

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BLM Polyclonal Antibody

Product Details

A300-110A

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:10,000
-

Immunoprecipitation (IP)

2-10 µg/mg lysate
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Region between residue 1375 and the C-terminus (residue 1417) of human Bloom Syndrome.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

phosphate/tris citrate, pH 7-8

Contains

0.09% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Bloom syndrome homolog; Bloom syndrome protein; Bloom syndrome protein homolog; Bloom syndrome RecQ like helicase; Bloom syndrome, RecQ helicase-like; DNA 3'-5' helicase BLM; DNA helicase, RecQ-like type 2; mBLM; MGC126616; MGC131618; MGC131620; RecQ helicase homolog; RecQ protein-like 3; RecQ-like DNA helicase BLM; RecQ2; unnamed protein product

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Gene Aliases: BLM; BS; MGRISCE1; RECQ2; RECQL2; RECQL3

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UniProt ID: (Human) P54132, (Mouse) O88700

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Entrez Gene ID: (Human) 641, (Mouse) 12144

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Function(s)
nucleotide binding four-way junction DNA binding Y-form DNA binding bubble DNA binding p53 binding nucleic acid binding DNA binding DNA helicase activity single-stranded DNA binding helicase activity protein binding ATP binding DNA-dependent ATPase activity zinc ion binding four-way junction helicase activity hydrolase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides isomerase activity ATPase activity identical protein binding protein homodimerization activity 3'-5' DNA helicase activity metal ion binding G-quadruplex DNA binding forked DNA-dependent helicase activity telomeric D-loop binding telomeric G-quadruplex DNA binding 8-hydroxy-2'-deoxyguanosine DNA binding DNA/DNA annealing activity catalytic activity ATP-dependent DNA helicase activity ATP-dependent helicase activity annealing helicase activity ATP-dependent 3'-5' DNA helicase activity DNA helicase
Process(es)
regulation of cyclin-dependent protein serine/threonine kinase activity telomere maintenance double-strand break repair via homologous recombination DNA double-strand break processing DNA replication DNA repair DNA recombination cellular response to DNA damage stimulus mitotic G2 DNA damage checkpoint response to X-ray replication fork processing telomere maintenance via semi-conservative replication DNA geometric change positive regulation of transcription, DNA-templated negative regulation of DNA recombination protein oligomerization protein homooligomerization negative regulation of cell division telomeric D-loop disassembly resolution of recombination intermediates cellular response to ionizing radiation cellular response to hydroxyurea cellular response to camptothecin t-circle formation DNA strand renaturation DNA duplex unwinding cellular metabolic process negative regulation of mitotic recombination alpha-beta T cell differentiation positive regulation of alpha-beta T cell proliferation regulation of binding chromosome organization negative regulation of thymocyte apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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